Ingredient

Niacinamide (Vitamin B3)

A versatile, well-tolerated active that addresses pigmentation, barrier strength, and inflammation simultaneously.

  • Best for

    Uneven Tone + Sensitivity

  • Best to

    Even + Strengthen + Calm

  • Compatibility

    Works with All Actives

  • Use

    AM + PM

Niacinamide (Vitamin B3)

What is it

What is Niacinamide (Vitamin B3)?

Niacinamide, also known as Vitamin B3 or nicotinamide, is a water-soluble vitamin that has become one of the most versatile actives in modern dermatology. It works through several distinct biological pathways, addressing both visible concerns like pigmentation and texture, and deeper functional concerns like barrier integrity.

MDAiRE ingredient benefits — ecm-eye

Benefits

What does Niacinamide (Vitamin B3) do for your skin?

Niacinamide has been shown in multiple clinical studies to reduce melanin transfer, support ceramide production, reduce inflammation, and improve overall skin quality - all without irritation. Key actions include:

  • Reduces the appearance of dark spots, hyperpigmentation, and uneven skin tone
  • Visibly minimizes the appearance of fine lines, wrinkles, and enlarged pores
  • Reduces the appearance of dark circles and puffiness around the eyes
  • Strengthens the skin barrier by boosting ceramide production
  • Calms inflammation and supports skin comfort in reactive skin types
MDAiRE ingredient how to_use — ecm-eye

How to use

How does Niacinamide (Vitamin B3) fit your routine?

Niacinamide is compatible with virtually all other actives, including Vitamin C and retinol, and can be used morning and evening without concern. Layer it in thin-to-thick order alongside other serums and treatments.

Who should use it

Who should use Niacinamide (Vitamin B3)?

Suitable for all skin types, including sensitive, acne-prone, and rosacea-adjacent skin. Ideal for those targeting both pigmentation and aging concerns simultaneously.

Formulated with

MDAiRE products formulated with Niacinamide (Vitamin B3)

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Regenerative ECM Eye Complex

Reduce dark circles, puffiness, and fine lines using clinical actives formulated specifically for the delicate eye area where the skin is thinnest and most demanding. 15 ml Bottle...

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RXR Retinol Anti-Aging Serum

1% active retinol in a solid lipid encapsulation system formulated for nightly use on all skin types, including retinol-sensitive skin. A multi-active, anti-aging blend promotes cellular turnover to...

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Clear Fusion Sunscreen

High Performance broad-spectrum mineral UV protection in a completely invisible, non-tinted formula to protect skin from UVA, UVB, and environmental stressors.   2.0 FL OZ  KEY INGREDIENTS Zinc Oxide: A...

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Body Tyte

Revitalizing body lotion that brings the clinical standards of your facial skincare to the rest of your skin. With peptides, retinol, ceramides, and caffeine, it improves firmness, smoothness,...

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Eye Bright Masks

Intensive treatment for your under-eye. Hydrogel patches deliver a concentrated dose of depuffing, brightening, and hydrating actives under sustained contact giving you visibly refreshed, awake-looking eyes in minutes. ...

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